Climbazole

Climbazole

 

  1. Basic Information
Product name Climbazole
CAS No. 38083-17-9
EINECS No. 253-775-4
Molecular Formula: C15H17ClN2O2
Molecular Weight: 292.76
Structural Formula:  

 

  1. Technical Specification of Climbazole
Item Specification
Appearance White crystalline powder
Purity(GC)% 99.0Min
Chloride 0.10Max
P-Chlorophenol 0.015Max
Residue on ignition 0.3Max
Water 0.50Max
Melting Point 96-98
Solubility Benzyl alcohol (approx) – 55%Ethanol (96%) – 50%

Phenoxyethanol – 40%; Ethoxydiglycol – 30%

Propylene Glycol – 30%; Butylene Glycol – 30%

Dipropylene Glycol – 30%; Certain perfume oils – 50%

Climbazole is soluble in alcohol, glycols, surfactants and perfume oils but, is insoluble in water.

 

  1. Application field

Climbazole is a powerful anti-dandruff active with a long history of successful use. Climbazole provides excellent activity against the main cause of dandruff, Malassezia species. Climbazole has a good antifungal ability, and has an inhibitory effect on the spore-like spores or Pityrosporum ovata that cause dandruff, as well as Candida albicans and Trichophyton. The mechanism is to eliminate the external factors that produce dandruff through sterilization and bacteriostasis, so as to achieve the effect of anti-itch.

Climbazole has a stable structure and will not cause irritation to the scalp due to hydrolysis. It is stable in acidic and slightly alkaline media, and has good stability to light and heat. It’s stable in acid and neutral pH ranges and not hygroscopic (does not absorb water from the air).

Climbazole is suitable for both leave-on and rinse-off hair care formulations.

Climbazole provides no formation of colored complexes with metal ions which cause discoloration in formulations. It has good compatibility with perfume oils and other commonly used hair care raw materials and is soluble in alcohol, glycols, surfactants and certain perfume oils. Climbazole has excellent light, heat and storage stability.

Climbazole is primarily aimed at haircare products where the anti-dandruff properties are renowned for their effectiveness. Climbazole however is found in some eczema treatments for its antifungal properties.

Climbazole has broad-spectrum bactericidal properties. It is mainly used for anti-itching and anti-dandruff conditioning shampoos and hair care shampoos. It can also be used for antibacterial soap, shower gel, medicated toothpaste, mouthwash, etc.

Recommended dosage: .4%~0.8%;

 

  1. Packing

Standard packaging includes the following:

25kg per drum, Other package sizes are available upon request.

 

  1. Storage

Store in a well-ventilated, cool, dry area, out of direct sunlight. Keep containers tightly closed when not in use.

 

  1. Period of validity

36 months